Anemia in cancer

被引：116

作者：

Dicato, M. ^{[1
]}

Plawny, L.

Diederich, M. ^{[1
]}

机构：

[1] Ctr Hosp Luxembourg, Lab Fdn Res Canc & Blood Disorders, L-1210 Luxembourg, Luxembourg

来源：

ANNALS OF ONCOLOGY | 2010年 / 21卷

关键词：

cancer; cytokines; erythropoietin; GATA-1; GATA-2; TNF-a; ERYTHROPOIESIS-STIMULATING AGENTS; EPOETIN-ALPHA; DARBEPOETIN ALPHA; DOUBLE-BLIND; BLOOD-TRANSFUSIONS; INTRAVENOUS IRON; CONTROLLED-TRIAL; CHEMOTHERAPY; RECEPTOR; HEMOGLOBIN;

D O I：

10.1093/annonc/mdq284

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), among others, play a major role in the pathophysiology of anemia in the cancer patient not only through complex mechanisms of the purely inflammatory situation but also through genetic regulatory aspects of erythropoiesis via GATA-1 and GATA-2, and other factors. In terms of therapy, iron is used more and more; the late side effects of transfusions are not really understood and the recent controversy regarding erythropoietin usage has resulted in regulatory authorities and scientific societies providing several recommendations and guidelines. These various aspects are addressed herein.

引用

页码：167 / 172

页数：6

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