Formal total synthesis of nikkomycin B based on a lipase-catalysed hydrolysis of an acetate possessing two stereogenic centers

被引：18

作者：

Akita, H ^{[1
]}

Chen, CY ^{[1
]}

Kato, K ^{[1
]}

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 37期

关键词：

D O I：

10.1016/S0040-4020(98)00647-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of the versatile chiral synthon possessing two stereogenic centers, (2S,3S)-11 (>99% ee) was achieved by using chemo-enzymatic method The conversion of (2S,3S)-11 into the homochiral intermediates (2S,3S,4S)-25 and (2S,3S,4S)-27 corresponding to the N-terminal amino acid moiety of nikkomycin B (1) and their application to the formal total synthesis of nikkomycin B (1) are described. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：11011 / 11026

页数：16

共 29 条

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