Albumin-alginate-coated microspheres: Resistance to steam sterilization and to lyophilization

被引：17

作者：

Callewaert, Maiete

Laurent-Maquin, Dorninique

Edwards-Levy, Florence

机构：

[1] Univ Reims, CNRS FRE 2715, IFR 53, Fac Pharm, F-51100 Reims, France

[2] Univ Reims, INSERM ERM 0203, IFR 53, Fac Odontol, F-51100 Reims, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 344卷 / 1-2期

关键词：

alginate; binding properties; lyophilization; microsphere; transacylation; sterilization;

D O I：

10.1016/j.ijpharm.2007.05.053

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The paper describes the effect of different thermal treatments on the morphology and binding properties of particles prepared using a transacylation reaction between two biocompatible polymers, namely propylene glycol alginate and human serum albumin. Compared to control alginate gel microspheres, albumin-alginate covalent network offers a better resistance to the microspheres towards freezing, lyophilization and sterilization. The binding properties for methylene blue were not altered by the treatments. Moreover, stability in physiological environments opens interesting applications in biological and pharmaceutical fields. (C) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：161 / 164

页数：4

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