Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea

被引:25
作者
Kadva, A [1 ]
Djahanbakhch, O
Monson, J
Di, WL
Silman, R
机构
[1] St Bartholomews & Royal London Sch Med & Dent, Dept Obstet & Gynaecol, London E1 1BB, England
[2] St Bartholomews & Royal London Sch Med & Dent, Dept Endocrinol, London E1 1BB, England
关键词
D O I
10.1210/jc.83.10.3653
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Elevated nocturnal melatonin is found in women with idiopathic hypogonadotropic hypogonadism (IHH), but it is not known whether this is implicated in the etiology of their GnRH deficiency. It is unlikely that nocturnal melatonin can be implicated in the etiology of the GnRH deficiency of Kallmann's syndrome (KS), because this condition is caused by defective neuronal migration in embryonic life. We therefore measured nocturnal melatonin in women with IHH and KS to determine whether it was elevated in one or both conditions and thereby to determine whether it was implicated as cause or consequence of GnRH deficiency. Four women with IHH, 3 women with KS, and 7 individually matched (age and body size) controls were recruited. Frequent day- and nighttime samples were taken for LH pulsatility studies. All patients showed absent or diminished LH pulsatility, compared with their respective controls. Samples were also taken over 24 h for melatonin and 6-sulphatoxymelatonin (the principle metabolite of melatonin and an independent marker of its secretion). Melatonin and 6-sulphatoxymelatonin levels were elevated in 6 of 7 patients (compared with their matched controls) and were significantly elevated in the KS group (compared with their controls). The finding pf elevated nocturnal melatonin (and its metabolite) in GnRH-deficient women with KS (as well as IHH) suggests that nocturnal melatonin is elevated as a consequence of GnRH deficiency, irrespective of its etiology.
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页码:3653 / 3662
页数:10
相关论文
共 17 条
[1]   PULSATILE SECRETION OF LH, FSH, PROLACTIN, ESTRADIOL AND PROGESTERONE DURING THE HUMAN MENSTRUAL-CYCLE [J].
BACKSTROM, CT ;
MCNEILLY, AS ;
LEASK, RM ;
BAIRD, DT .
CLINICAL ENDOCRINOLOGY, 1982, 17 (01) :29-42
[2]   CIRCADIAN PATTERN OF PLASMA MELATONIN CONCENTRATIONS DURING 4 PHASES OF THE HUMAN MENSTRUAL-CYCLE [J].
BERGA, SL ;
YEN, SSC .
NEUROENDOCRINOLOGY, 1990, 51 (05) :606-612
[3]   AMPLIFICATION OF NOCTURNAL MELATONIN SECRETION IN WOMEN WITH FUNCTIONAL HYPOTHALAMIC AMENORRHEA [J].
BERGA, SL ;
MORTOLA, JF ;
YEN, SSC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (01) :242-244
[4]  
BOJOWSKY CJ, 1987, CLIN CHEM, V33, P1343
[5]   THE CIRCADIAN-RHYTHM OF PLASMA MELATONIN DURING THE NORMAL MENSTRUAL-CYCLE AND IN AMENORRHEIC WOMEN [J].
BRZEZINSKI, A ;
LYNCH, HJ ;
SEIBEL, MM ;
DENG, MH ;
NADER, TM ;
WURTMAN, RJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (05) :891-895
[6]   CLINICAL COUNTERPOINT - GONADOTROPIN-RELEASING-HORMONE DEFICIENCY - PERSPECTIVES FROM CLINICAL INVESTIGATION [J].
CROWLEY, WF ;
JAMESON, JL .
ENDOCRINE REVIEWS, 1992, 13 (04) :635-640
[7]  
DELFS TM, 1994, HUM REPROD, V9, P40
[8]  
Di WL, 1998, CLIN CHEM, V44, P304
[9]   INCREASED NOCTURNAL MELATONIN SECRETION IN MALE-PATIENTS WITH HYPOGONADOTROPIC HYPOGONADISM AND DELAYED PUBERTY [J].
LUBOSHITZKY, R ;
LAVI, S ;
THUMA, I ;
LAVIE, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (07) :2144-2148
[10]   Decreased nocturnal melatonin secretion in patients with Klinefelter's syndrome [J].
Luboshitzky, R ;
Wagner, O ;
Lavi, S ;
Herer, P ;
Lavie, P .
CLINICAL ENDOCRINOLOGY, 1996, 45 (06) :749-754