Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups

被引：87

作者：

Peng, Qi ^{[1
]}

Chen, Fujie ^{[1
]}

Zhong, Zhenlin ^{[1
]}

Zhuo, Renxi ^{[1
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Dept Chem, Wuhan 430072, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 32期

基金：

中国国家自然科学基金;

关键词：

DESIGN; RECEPTORS; MEMBRANE; VECTORS; HEPARIN; SENSOR; CELLS;

D O I：

10.1039/c0cc00877j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl) phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.

引用

页码：5888 / 5890

页数：3

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