Elusive radial glial cells: Historical and evolutionary perspective

被引:192
作者
Rakic, P [1 ]
机构
[1] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
关键词
neurogenesis; gliogenis; corticogenesis; neuonal migration; brain evolution;
D O I
10.1002/glia.10244
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Since the discovery of radial glial cells in the human fetal forebrain, this specialized cellular population has been identified in most regions of the vertebrate brain during restricted developmental periods. However, their size, longevity, and significance for guiding migrating neurons have increased with the evolutionary expansion of the mammalian neocortex, reaching a peak in the gyrencephalic human forebrain. The phenotypic distinction of radial glial cells from the more specialized neuronal progenitors in the proliferative zones and from the migrating neurons in the intermediate zone of the primate fetal forebrain, based initially on, morphological criteria, has been supported by their ultrastructural, molecular, and physiological characteristics. In addition, modern in vivo and in vitro approaches revealed that these specialized embryonic cells can also generate neuronal cell lines, which either immediately, or after several divisions, migrate along radial shaft processes of the mother cells that span the expanding and convoluted cerebral wall. The multiple functions of radial glial cells and their species-specific adaptations indicate a pivotal role in evolution, development, and pathology of the cerebral neocortex. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:19 / 32
页数:14
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