The remission of rheumatoid arthritis during pregnancy

被引：127

作者：

Ostensen, Monika ^{[1
]}

Villiger, Peter M. ^{[1
]}

机构：

[1] Univ Hosp Bern, Clin Rheumatol & Clin Immunol, CH-3010 Bern, Switzerland

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2007年 / 29卷 / 02期

关键词：

pregnancy; rheumatoid arthritis; hormones; immune response; microchimerism;

D O I：

10.1007/s00281-007-0072-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatoid arthritis ( RA) is an autoimmune disease that is favorably influenced by pregnancy but relapses after delivery. A variety of circulating factors has been considered as candidates for inducing gestational improvement of RA; however, the factors/ pathways responsible remain still elusive. This review discusses recent research on the effect of pregnancy on RA with a focus on immunregulation, cytokine secretion, HLA antigens, microchimerism, and innate immunity. The complex hormonal and immunological alterations of pregnancy may temporarily correct the disturbed immunregulation of RA.

引用

页码：185 / 191

页数：7

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