Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus

被引：53

作者：

Abdel-Hakeem, Mohamed S. ^{[1
,2
]}

Bedard, Nathalie ^{[1
]}

Badr, Gamal ^{[1
]}

Ostrowski, Mario ^{[5
]}

Sekaly, Rafick P. ^{[1
,2
]}

Bruneau, Julie ^{[1
,4
]}

Willems, Bernard ^{[1
,3
]}

Heathcote, E. Jenny ^{[6
]}

Shoukry, Naglaa H. ^{[1
,3
]}

机构：

[1] Hop St Luc, Ctr Rech, CHUM, Montreal, PQ H2X 1P1, Canada

[2] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[3] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[4] Univ Montreal, Dept Med Familiale, Montreal, PQ H3C 3J7, Canada

[5] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[6] Toronto Western Hosp, Toronto, ON M5T 2S8, Canada

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 19期

关键词：

T-CELL RESPONSES; COMBINATION THERAPY; VIRAL PERSISTENCE; CHRONIC INFECTION; CD127; EXPRESSION; HCV INFECTION; CD8; RESPONSES; RIBAVIRIN; PEGINTERFERON; RESOLUTION;

D O I：

10.1128/JVI.01094-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Early alpha interferon (IFN-alpha) therapy against hepatitis C virus (HCV) rescues polyfunctional, virus-specific memory CD8(+) T cells, but whether immune restoration is possible during late therapy remains controversial. We compared immune restoration of HCV-specific memory T cells in patients who cleared HCV infection spontaneously and following early or late IFN therapy. Multifunctional CD4(+) and CD8(+) memory T cells were detected in spontaneous resolvers and in individuals treated early following an acute infection. In contrast, limited responses were detected in patients treated during chronic infection, and the phenotype of HCV-specific cells was influenced by autologous viral sequences. Our data suggest that irreversible damage to the HCV-specific memory T-cell response is associated with chronic HCV infection.

引用

页码：10429 / 10435

页数：7

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