The impact of tumor stroma on drug response in breast cancer

被引：75

作者：

Dittmer, Juergen ^{[1
]}

Leyh, Benjamin ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Clin Gynecol, D-06120 Halle, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2015年 / 31卷

基金：

芬兰科学院;

关键词：

Extra-cellular matrix; Carcinoma-associated fibroblast; Mesenchymal stem cell; Tumor-associated macrophage; Drug resistance; MESENCHYMAL STEM-CELLS; RECEPTOR TYROSINE KINASE; EXTRACELLULAR-MATRIX PROTEINS; BONE-MARROW STROMA; TGF-BETA; TAMOXIFEN RESISTANCE; GROWTH-FACTOR; INDUCED APOPTOSIS; ANTICANCER DRUG; TRASTUZUMAB RESISTANCE;

D O I：

10.1016/j.semcancer.2014.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In the last two decades the breast cancer mortality rate has steadily declined, in part, due to the availability of better treatment options. However, drug resistance still remains a major challenge. Resistance can be an inherent feature of breast cancer cells, but can also arise from the tumor microenvironment. This review aims to focus on the modulatory effect of the tumor microenvironment on the differing response of breast cancer subtypes to targeted drugs and chemotherapy. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3 / 15

页数：13

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