Highly chemo- and diastereoselective addition of diethylzinc through intramolecular autoactivation of enantiopure 2-acyl-1-formylferrocene:: application to the synthesis of optically pure 1,2-diacylferrocenes

被引：10

作者：

Malfait, S ^{[1
]}

Pélinski, L ^{[1
]}

Brocard, J ^{[1
]}

机构：

[1] Univ Sci & Technol Lille, Catalyse Heterogene & Homogene Lab, Grp Synth Organomet, CNRS,URA 402, F-59655 Villeneuve Dascq, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(98)00238-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantiomerically pure 1,2-diacylferrocenes (+)-(R)-10-12 (ee>99%) were synthesized from (N,N-dimethylaminomethyl)ferrocene via enantiomerically pure 2-acyl-l-formylferrocene (+)-(R)-4-6. A novel methodology was performed using the chemo- and diastereoselective addition of diethylzinc to the formyl function through an intramolecular autoactivation. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2207 / 2210

页数：4

共 22 条

[1] THE ROLE OF THE PRODUCT IN ASYMMETRIC C-C BOND FORMATION - STOICHIOMETRIC AND CATALYTIC ENANTIOSELECTIVE AUTOINDUCTION [J].