Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes

被引：68

作者：

Aragones, Gemma ^{[1
]}

Ferre, Raimon ^{[1
]}

Lazaro, Iolanda ^{[1
]}

Cabre, Anna ^{[1
]}

Plana, Nuria ^{[1
]}

Merino, Jordi ^{[1
]}

Heras, Mercedes ^{[1
]}

Girona, Josefa ^{[1
]}

Masana, Lluis ^{[1
]}

机构：

[1] Univ Rovira & Virgili, St Joan Univ Hosp, Vasc Med & Metab Unit,Internal Med Dept,IISPV, Res Unit Lipids & Atherosclerosis,CIBER Diabet &, Reus 43201, Spain

来源：

ATHEROSCLEROSIS | 2010年 / 213卷 / 01期

关键词：

FABP4; Endothelial function; Type; 2; diabetes; Reactive hyperemia; Inflammatory markers; Oxidative markers; Cardiovascular risk; PLASMA FATTY-ACID-BINDING-PROTEIN-4; ATHEROSCLEROSIS; EXPRESSION; DISEASE; AP2;

D O I：

10.1016/j.atherosclerosis.2010.07.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D. We have investigated the relationship between circulating FABP4 levels and endothelial function in diabetic patients. Methods: In 257 patients (105 diabetic and 152 non-diabetic) at increased risk of cardiovascular disease, we measured circulating FABP4, reactive hyperemia index (RHI) by peripheral artery tonometry, intimamedia thickness, and biomarkers of inflammation, oxidation and endothelial function. Results: In T2D subjects, FABP4 was negatively associated with endothelial function, as measured by RHI (r =-0.226, P = 0.05). In a stepwise multivariate linear regression model, FABP4 was a predictor of RHI in T2D patients (P = 0.04). Conclusion: Circulating levels of FABP4 are inversely associated with endothelial function in T2D patients, as measured by RHI. We suggest a direct effect of plasma FABP4 on the vascular endothelium in those with T2D. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：329 / 331

页数：3

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