From therapy to experimental model: a hundred years of endotoxin administration to human subjects

被引：84

作者：

Bahador, Marjan ^{[1
,2
]}

Cross, Alan S. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Dept Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Div Infect Dis, Dept Med, Baltimore, MD 21201 USA

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2007年 / 13卷 / 05期

关键词：

endotoxin; human subjects;

D O I：

10.1177/0968051907085986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article is a review of studies in which endotoxin has been administered to human subjects for experimental purposes. Data are presented in tabular form so the reader can better appreciate the objectives of individual studies. Although the original intention was to focus on the adverse events associated with these studies, unexpected serious adverse events rarely have been reported.

引用

页码：251 / 279

页数：29

共 179 条

[1] Insulin resistance and substrate utilization in human endotoxemia [J].

Agwunobi, AO ;

Reid, C ;

Maycock, P ;

Little, RA ;

Carlson, GL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (10) :3770-3778

[2] Differential release of matrix metalloproteinase-9 and nitric oxide following infusion of endotoxin to human volunteers [J].

Albert, J ;

Radomski, A ;

Soop, A ;

Sollevi, A ;

Frostell, C ;

Radomski, MW .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2003, 47 (04) :407-410

[3] PRETREATMENT OF NORMAL HUMANS WITH MONOPHOSPHORYL LIPID-A INDUCES TOLERANCE TO ENDOTOXIN - A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED, CONTROLLED TRIAL [J].

ASTIZ, ME ;

RACKOW, EC ;

STILL, JG ;

HOWELL, ST ;

CATO, A ;

VONESCHEN, KB ;

ULRICH, JT ;

RUDBACH, JA ;

MCMAHON, G ;

VARGAS, R ;

STERN, W .

CRITICAL CARE MEDICINE, 1995, 23 (01) :9-17

[4]

Beebe SP, 1907, J AMER MED ASSOC, V49, P1493

[5] TOLERANCE TO BACTERIAL PYROGENS .1. FACTORS INFLUENCING ITS DEVELOPMENT [J].

BEESON, PB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1947, 86 (01) :29-38

[6] TOLERANCE TO BACTERIAL PYROGENS .2. ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM [J].

BEESON, PB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1947, 86 (01) :39-44

[7] Quantitative analysis of von Willebrand factor propeptide release in vivo: Effect of experimental endotoxemia and administration of 1-deamino-8-D-arginine vasopressin in humans [J].

Borchiellini, A ;

Fijnvandraat, K ;

tenCate, JW ;

Pajkrt, D ;

vanDeventer, SJH ;

Pasterkamp, G ;

MeijerHuizinga, F ;

ZwartHuinink, L ;

Voorberg, J ;

vanMourik, JA .

BLOOD, 1996, 88 (08) :2951-2958

[8] Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans [J].

Bornstein, SR ;

Preas, HL ;

Chrousos, GP ;

Suffredini, AF .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (03) :887-890

[9] COMPARTMENTALIZATION OF THE ACUTE CYTOKINE RESPONSE IN HUMANS AFTER INTRAVENOUS ENDOTOXIN ADMINISTRATION [J].

BOUJOUKOS, AJ ;

MARTICH, GD ;

SUPINSKI, E ;

SUFFREDINI, AF .

JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (06) :3027-3033

[10] Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia [J].

Branger, J ;

van den Blink, B ;

Weijer, S ;

Madwed, J ;

Bos, CL ;

Gupta, A ;

Yong, CL ;

Polmar, SH ;

Olszyna, DP ;

Hack, CE ;

van Deventer, SJH ;

Peppelenbosch, MP ;

van der Poll, T .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :4070-4077

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