Stem Cells Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies

被引：6

作者：

Banerjee, Chaitali ^{[1
]}

机构：

[1] BiomedOne, Rexford, NY 12148 USA

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2011年 / 12卷 / 04期

关键词：

Stem cells; cell therapy; biomarkers; biomedical imaging; molecular imaging; REPORTER GENE-EXPRESSION; PANCREATIC BETA-CELLS; MONOCYTE-DERIVED NEOHEPATOCYTES; SYNTHETIC RENILLA LUCIFERASE; PROTEIN-PROTEIN INTERACTIONS; MESENCHYMAL STROMAL CELLS; BONE-MARROW STEM; IN-VIVO; PROGENITOR CELLS; IRON-OXIDE;

D O I：

10.2174/138920111795164002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Stem-cell technology is a major area within cell therapy that promises significant therapeutic outcome. The plasticity and self-renewal capabilities of stem cells make them valuable tools for potential application in regenerative medicine and tissue replacement following injury or disease. Here, we discuss the different types of stem cells currently used in research, preclinical and early clinical development, their potential therapeutic and diagnostic applications, and current barriers to translating basic research into clinical therapies. Biomedical imaging is increasingly being used to monitor the fate of transplanted stem cells, including their survival, proliferation, differentiation and homing to targeted organs and tissues. We discuss different imaging modalities currently utilized to track stem calls, the advantages and challenges, and future implications in clinical applications.

引用

页码：469 / 487

页数：19

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