Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry

被引：28

作者：

Baker, Matthew J. ^{[1
]}

Brown, Michael D. ^{[2
]}

Gazi, Ehsan ^{[2
]}

Clarke, Noel W. ^{[2
,3
,4
]}

Vickerman, John C. ^{[1
]}

Lockyer, Nicholas P. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem Engn & Analyt Sci, Ctr Instrumentat & Analyt Sci, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England

[2] Univ Manchester, Christie Hosp NHS Fdn Trust, Paterson Inst Canc Res, ProMPT Genito Urinary Canc Res Grp, Manchester M20 4BX, Lancs, England

[3] Christie Hosp NHS Fdn Trust, Dept Urol, Manchester M20 4BX, Lancs, England

[4] Salford Royal NHS Fdn Trust, Dept Urol, Salford M6 8HD, Lancs, England

来源：

ANALYST | 2008年 / 133卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1039/b712853c

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions.

引用

页码：175 / 179

页数：5

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