5-Lipoxygenase and atherosclerosis

被引：93

作者：

Mehrabian, M

Allayee, H

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2003年 / 14卷 / 05期

关键词：

atherosclerosis; genetics; leukotriene biosynthetic pathway; 5-lipoxygenase;

D O I：

10.1097/00041433-200310000-00005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of review 5-Lipoxygenase (5LO) was recently identified as a gene that makes an important contribution to atherosclerosis in mice and humans, but the underlying mechanism(s) remains unknown. Recent findings Studies of the 5LO pathway in other disease areas suggest that 5LO could contribute to atherosclerosis at different levels, such as lesion initiation, growth and cellular proliferation within the lesion, and/or destabilization of plaques that can lead to their rupture. Summary Recent advances in our understanding of how 5LO is involved in the atherosclerotic process will have important implications for diagnostic and therapeutic strategies in the future.

引用

页码：447 / 457

页数：11

共 95 条

[1] Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice [J].