Photochemical synthesis of novel dideoxynucleosides

被引：11

作者：

Lee-Ruff, E ^{[1
]}

Margau, R ^{[1
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1081/NCN-100002080

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 2 ' ,3 ' -dideoxynucleosides based on the apiose family was prepared from photochemical ring-expansion of a common cyclobutanone precursor. The starting ketone, (+/-) 3-[2 '-(benzoyloxy)ethyl]-2,2-dimethylcyclobutanone (12) was prepared from commercially available (+/-)alpha -pinene. Since the optically pure antipodes of alpha -pinene are also commercially available, these nucleosides can be prepared optically pure using the identical procedure.

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页码：185 / 196

页数：12

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