Mechanical response and multilevel structure of biomimetic hydroxyapatite/polygalacturonic/chitosan nanocomposites

被引：43

作者：

Verma, Devendra ^{[1
]}

Katti, Kalpana S. ^{[1
]}

Katti, Dinesh R. ^{[1
]}

Mohanty, Bedabibhas ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Civil Engn, Fargo, ND 58105 USA

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2008年 / 28卷 / 03期

基金：

美国国家科学基金会;

关键词：

bone; biomaterials; chitosan; hydroxyapatite; polygalacturonic acid;

D O I：

10.1016/j.msec.2007.04.026

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Using an in situ mineralization process that is biomimetic we have synthesized new nanocomposites of chitosan/hydroxyapatite in 50-50 ratio (ChiHAP50), polygalacturonic acid/hydroxyapatite in 50-50 ratio (PgAHAP50) and Chitosan/hydroxyapatite/Polygalacturonic acid (ChiPgAHAP50). Polygalacturonic acid (PgA) is electrostatically complementary to chitosan, and thus is expected to provide stronger interfacial interactions and improve mechanical response. Atomic force imaging of fractured and polished surfaces suggests a multilevel organization in the hydroxyapatite/biopolymer nanocomposite. The AFM images of ChiPgAHAP50 nanocomposite display presence of chitosan rich and polygalacturonic rich domains. These chitosan rich and PgA rich domains are made of smaller globular shaped particles in which, hydroxyapatite nano-particles are embedded in the biopolymer matrix. The average size of the hydroxyapatite particles in PgAHAP50, ChiHAP50 and ChiPgAHAP50 were found to be 25, 42 and 34 nm respectively. The elastic moduli determined from nanoindentation of PgAHAP50, ChiHAP50 and ChiPgAHAP50 composites are 29.81, 17.56 and 23.62 GPa respectively. Hardness values of the three composites in the same order were found to be 1.56, 0.65 and 1.14 GPa respectively. Macro-mechanical tests showed significant enhancement in elastic moduli, strain to failure and compressive strength of ChiPgAHAP50 composites over ChiHAP50 and PgAHAP50. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：399 / 405

页数：7

共 41 条

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