Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis

被引：82

作者：

Desplat-Jégo, S

Creidy, R

Varriale, S

Allaire, N

Luo, Y

Bernard, D

Hahm, K

Burkly, L

Boucraut, J

机构：

[1] Fac Med Marseille, CNRS, NICN, UMR 6184, F-13385 Marseille, France

[2] Univ Mediterranee, CNRS, UMR 6184, NICN, F-13916 Marseille, France

[3] Biogen Idec, Exploratory Sci, Cambridge, MA 02142 USA

来源：

CLINICAL IMMUNOLOGY | 2005年 / 117卷 / 01期

关键词：

TWEAK; Fn14; experimental autoimmune encephalomyelitis; therapy; neutralizing antibody;

D O I：

10.1016/j.clim.2005.06.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TWEAK is a member of the TNF family, constitutively expressed in the central nervous system (CNS), with pro-inflammatory, proliferative or apoptotic effects depending upon cell types. Its receptor, Fn14, is expressed in CNS by endothelial cells, reactive astrocytes and neurons. We showed that TWEAK and Fn14 mRNA expression increased in spinal cord during experimental autoimmune encephalomyelitis (EAE). We investigated the role of TWEAK during EAE using neutralizing anti-TWEAK antibody in myelin oligodendrocyte glycoprotein (MOG) induced EAE in C57BL/6 mice. We observed a reduction of disease severity and leukocyte infiltration when mice were treated after the priming phase. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：15 / 23

页数：9

共 54 条

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