PMWS: experimental model and co-infections

被引：55

作者：

Allan, GM

McNeilly, F

Ellis, J

Krakowka, S

Botner, A

McCullough, K

Nauwynck, H

Kennedy, S

Meehan, B

Charreyre, C

机构：

[1] DARDNI, Vet Sci Div, Vet Res Lab, Dept Virol, Belfast BT4 3SD, Antrim, North Ireland

[2] Merial SAS, Lyon, France

[3] State Univ Ghent, Virol Lab, B-9000 Ghent, Belgium

[4] Inst Virol & Immunoprophylaxis, Mittelhausern, Switzerland

[5] Danish Vet Inst Virus Res, Lindholm, Denmark

[6] Ohio State Univ, Columbus, OH 43210 USA

[7] Univ Saskatchewan, Dept Vet Microbiol, Saskatoon, SK S7N 0W0, Canada

来源：

VETERINARY MICROBIOLOGY | 2004年 / 98卷 / 02期

关键词：

porcine; circovirus; experimental infection; wasting;

D O I：

10.1016/j.vetmic.2003.10.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine circovirus type 2 (PCV2) is now recognised as the causal agent of porcine multisystemic wasting syndrome (PMWS), an economically important wasting disease of young pigs [J. Vet. Diagn. Invest. 12 (2000) 3]. Gross lesions of PMWS include generalised lymphadenopathy, hepatitis, nephritis and pneumonia and typical histological lesions include lymphocytic depletion and multinucleated giant cell formation in lymph nodes, degeneration and necrosis of hepatocytes, and multifocal lymphohistocytic interstitial pneumonia. This communication will review the results of experimental infections of gnotobiotic (GN), colostrum-deprived (CD) and colostrum-fed (CF) pigs within our group, and elsewhere, with PCV2 and the conclusions that can be drawn from this work. (C) 2003 Elsevier B.V. All rights reserved.

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页码：165 / 168

页数：4

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