Functionalized amino acid anticonvulsants: Synthesis and pharmacological evaluation of conformationally restricted analogues

被引：75

作者：

LeTiran, A

Stables, JP

Kohn, H ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA

[2] Univ Houston, Dept Chem, Houston, TX 77204 USA

[3] NINCDS, Epilepsy Branch, NIH, Bethesda, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(01)00204-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proven conformationally restricted analogues of anticonvulsant functionalized amino acids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2693 / 2708

页数：16

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