2′/3′-O-peptidyl adenosine as a general base catalyst of its own external peptidyl transfer:: Implications for the ribosome catalytic mechanism

被引：32

作者：

Changalov, MM

Ivanova, GD

Rangelov, MA

Acharya, P

Acharya, S

Minakawa, N

Földesi, A

Stoineva, IB

Yomtova, VM

Roussev, CD

Matsuda, A

Chattopadhyaya, J

Petkov, DD ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, Lab BioCatalysis, BU-1113 Sofia, Bulgaria

[2] Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden

[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 060, Japan

[4] Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60439 Frankfurt, Germany

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 06期

关键词：

catalysis; neighboring-group effects; reaction mechanisms; ribosomes; transesterification;

D O I：

10.1002/cbic.200400349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A physical organic study reveals general base catalysis by the 2′-oxyanion of the peptidyl adenosine ethanolysis; this implies a proton-shuttle role for the 2′-OH of peptidyl tRNA A76 in the ribosome substrate-assisted catalytic mechanism. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：992 / 996

页数：5

共 33 条

[1] New C-2 symmetrical and semisymmetrical substituted imidazolium ribonucleoside. Imidazolic nucleosides analogues [J].