Oleoyl-estrone does not alter hypothalamic neuropeptide Y in Zucker lean and obese rats

被引：9

作者：

Cabot, C

Del mar Grasa, M

Adán, C

Pérez-Clausell, J

Virgili, J

Estruch, J

Fernández-Löpez, JA

Remesar, X

Alemany, M

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

[2] Labs SALVAT SA, Barcelona 08950, Spain

[3] Univ Barcelona, Fac Biol, Dept Biol Cellular Anim & Vegetal, E-08028 Barcelona, Spain

来源：

PEPTIDES | 1998年 / 19卷 / 09期

关键词：

neuropeptide Y; oleoyl-estrone; appetite; hypothalamus; energy expenditure; obesity; Zucker obese rat; Merlin-2;

D O I：

10.1016/S0196-9781(98)00104-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Female Zucker lean and obese rats were treated for 14 days with 3.5 mu mol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptide Y (NPY) radioimmunoassay. In 14 days, OE decreased food intake by 26% in lean and 38% in obese rats and energy expenditure by 6% in lean and 47% in obese rats; the body weight gap between controls and treated rats becoming -17.8% of initial b.wt. in the lean and -13.6% in the obese rats. Obese rats showed higher NPY levels in all the nuclei than the lean rats. Despite a negative energy balance and decreased food intake, there were practically no changes in NPY with OE treatment. The results indicate that oleoyl-estrone does not act through NPY in its control of either food intake or thermogenesis in lean and genetically obese rats. (C) 1998 Elsevier Science Inc.

引用

页码：1631 / 1635

页数：5

共 30 条

[1]

[Anonymous], 1993, BIOL NEUROPEPTIDE RE, DOI DOI 10.1007/978-1-59259-465-8_11

[2] AN ARCUATO-PARAVENTRICULAR AND ARCUATO-DORSOMEDIAL HYPOTHALAMIC NEUROPEPTIDE Y-CONTAINING SYSTEM WHICH LACKS NORADRENALINE IN THE RAT [J].