Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media

被引：30

作者：

Coisne, S ^{[1
]}

Béchet, M ^{[1
]}

Blondeau, R ^{[1
]}

机构：

[1] Univ Sci & Technol Lille, Microbiol Lab, F-59655 Villeneuve Dascq, France

来源：

LETTERS IN APPLIED MICROBIOLOGY | 1999年 / 28卷 / 03期

关键词：

Antibiotics; -; Bacteria; Ketones;

D O I：

10.1046/j.1365-2672.1999.00509.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Production of the polyketide antibiotic actinorhodin by Streptomyces coelicolor A3(2) was investigated using a defined medium with or without iron supplementation. Iron limitation was found to enhance the intracellular production and export of the pigmented antibiotic. The effect of iron deficiency was particularly pronounced when the bacterium was grown with nitrate instead of ammonium. Analysis of the excreted pigment led to the identification of the lactone form of actinorhodin, gamma-actinorhodin.

引用

页码：199 / 202

页数：4

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