The synaptic Aβ hypothesis of Alzheimer disease

被引：178

作者：

Tanzi, RE ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Genet & Aging Res Unit, Charlestown, MA 02129 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 08期

关键词：

D O I：

10.1038/nn0805-977

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A beta peptide is linked to Alzheimer pathology, but its toxic mechanism remains unclear. New work shows that A leads to internalization of NMDA receptors, reducing their availability at synapses. The authors also suggest a molecular mechanism for this endocytosis.

引用

页码：977 / 979

页数：4

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