New quinolones and the impact on resistance

被引：21

作者：

Dougherty, TJ ^{[1
]}

Beaulieu, D ^{[1
]}

Barrett, JF ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Microbiol, Wallingford, CT 06492 USA

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 10期

关键词：

D O I：

10.1016/S1359-6446(01)01760-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The changes in quinolone research have been fast and exciting over the past 5-7 years with the discovery and development of several new 8-methoxy quinolones. An additional factor is the design of the so-called 4th-generation quinolones that lack the C-6 fluorine, which might impact the development of quinolone resistance. The science behind the quinolone susceptibility and resistance patterns is fascinating, but has not yet been clearly delineated in discussions of the advantages of quinolone usage in the clinic.

引用

页码：529 / 536

页数：8

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