Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats

被引：104

作者：

de Almeida, RN

Motta, SC

Faturi, CD

Catallani, B

Leite, JR

机构：

[1] Univ Fed Paraiba, Dept Physiol & Pathol LTF, BR-58051970 Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Sao Paulo, Dept Psychobiol, BR-04023062 Sao Paulo, Brazil

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2004年 / 77卷 / 02期

关键词：

rose oil; elevated plus-maze; rats; anxiety; diazepam; inhalation;

D O I：

10.1016/j.pbb.2003.11.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of rose oil inhalation (1.0%, 2.5%, and 5.0% w/w) on the elevated plus-maze (EPM) test was investigated in adult male rats and compared with the effect of diazepam (DZP) (1.0 and 2.0 mg/kg) administered intraperitoneally 30 min before testing. Exposure to rose oil produced an anxiolytic-like effect similar to DZP (anxiolytic reference drug). Thus, at some concentrations, rose oil significantly increased the number of visits to and time spent in the open arms of the EPM. Anxiolytic-like properties of rose oil were observed using the EPM, being consistent with other behavioral and clinical studies. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：361 / 364

页数：4

共 21 条

[1] Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study [J].