Well-Tolerated Chemoprophylaxis Uniformly Prevented Swedish Soldiers from Plasmodium falciparum Malaria in Liberia, 2004-2006

被引：11

作者：

Andersson, Hakan ^{[1
]}

Askling, Helena H. ^{[2
]}

Falck, Bjorn ^{[1
]}

Rombo, Lars ^{[2
,3
]}

机构：

[1] Swedish Armed Forces, Stockholm, Sweden

[2] Karolinska Inst, Dept Med Solna, Infect Dis Unit, Stockholm, Sweden

[3] Sormland Cty Council, Clin Res Ctr, Eskilstuna, Sweden

来源：

MILITARY MEDICINE | 2008年 / 173卷 / 12期

关键词：

D O I：

10.7205/MILMED.173.12.1194

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Between 2004 and 2006, 1,170 Swedish soldiers were deployed to Liberia. They were prescribed mefloquine or atovaquone/proguanil as malaria chemoprophylaxis. Our study aims were to estimate the chemoprophylaxis effectiveness and adverse events. Methods: Cases of malaria were routinely reported during and after the mission. After return to Sweden, the soldiers filled in a questionnaire concerning type of accommodation, use of prophylaxis, and adverse events. Results: No cases of Plasmodium falciparum malaria were recorded during a total of 7,000 person-months. Adverse events (AE) were reported by 57% in the mefloquine group and 34% in the atovaquone/proguanil group. In the mefloquine group, the soldiers reported more neuropsychological AE. Conclusions: Both drugs were safe and 100% effective as lone-term prophylaxis for prevention of P. falciparum malaria. Atovaquone/proguanil was better tolerated with respect to self-reported AE.

引用

页码：1194 / 1198

页数：5

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