Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals

被引：27

作者：

Akazawa, Yoko Ogawa ^{[3
]}

Saito, Yoshiro ^{[1
,3
]}

Hamakubo, Takao ^{[2
]}

Masuo, Yoshinori ^{[3
]}

Yoshida, Yasukazu ^{[3
]}

Nishio, Keiko ^{[3
]}

Shichiri, Mototada ^{[3
]}

Miyasaka, Tomohiro ^{[1
]}

Iwanari, Hiroko ^{[2
]}

Mochizuki, Yasuhiro ^{[2
]}

Kodama, Tatsuhiko ^{[2
]}

Noguchi, Noriko ^{[1
]}

Niki, Etsuo ^{[3
]}

机构：

[1] Doshisha Univ, Fac Med & Life Sci, Dept Med Life Syst, Kyoto 6100394, Japan

[2] Univ Tokyo, Res Ctr Adv Sci & Technol, Lab Syst Biol & Med, Tokyo, Japan

[3] Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Osaka, Japan

来源：

NEUROSCIENCE LETTERS | 2010年 / 483卷 / 03期

基金：

日本学术振兴会;

关键词：

DJ-1; Oxidative stress; Parkinson's disease; Biomarker; Erythrocytes; Enzyme-linked immunosorbent assay; Antibody; DOPAMINE; PATHOGENESIS; MECHANISMS; ALZHEIMER; UPDATE; CELLS; MPTP; MICE;

D O I：

10.1016/j.neulet.2010.08.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than those in medicated PD patients and healthy subjects In the present study, we examined the changes in oxidized DJ-1 levels in the brain and erythrocytes of PD animal models using specific antibodies against Cys-106-oxidized DJ-1 Treatment with PD model compounds such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine significantly elevated the levels of oxidized DJ-1 in erythrocytes. Immunohistochemical analysis also revealed that the number of oxidized DJ-I antibody-positive cells in the substantia nigra of MPTP-treated mouse Increased in a dose-dependent manner These results suggest that the oxidative modification of DJ-1 in the brain and erythrocytes is involved in the pathogenesis of PD in animal models (C) 2010 Elsevier Ireland Ltd. All rights reserved

引用

页码：201 / 205

页数：5

共 21 条

[1] Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1 [J].

Blackinton, Jeff ;

Lakshminarasimhan, Mahadevan ;

Thomas, Kelly J. ;

Ahmad, Rili ;

Greggio, Elisa ;

Raza, Ashraf S. ;

Cookson, Mark R. ;

Wilson, Mark A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (10) :6476-6485

[2] Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease [J].

Blum, D ;

Torch, S ;

Lambeng, N ;

Nissou, MF ;

Benabid, AL ;

Sadoul, R ;

Verna, JM .

PROGRESS IN NEUROBIOLOGY, 2001, 65 (02) :135-172

[3] Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism [J].

Bonifati, V ;

Rizzu, P ;

van Baren, MJ ;

Schaap, O ;

Breedveld, GJ ;

Krieger, E ;

Dekker, MCJ ;

Squitieri, F ;

Ibanez, P ;

Joosse, M ;

van Dongen, JW ;

Vanacore, N ;

van Swieten, JC ;

Brice, A ;

Meco, G ;

van Duijn, CM ;

Oostra, BA ;

Heutink, P .

SCIENCE, 2003, 299 (5604) :256-259

[4] Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases [J].

Choi, J ;

Sullards, MC ;

Olzmann, JA ;

Rees, HD ;

Weintraub, ST ;

Bostwick, DE ;

Gearing, M ;

Levey, AI ;

Chin, LS ;

Li, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (16) :10816-10824

[5] Parkinson's disease: Mechanisms and models [J].

Dauer, W ;

Przedborski, S .

NEURON, 2003, 39 (06) :889-909

[6] PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model [J].

Inden, Masatoshi ;

Taira, Takahiro ;

Kitamura, Yoshihisa ;

Yanagida, Takashi ;

Tsuchiya, Daiju ;

Takata, Kazuyuki ;

Yanagisawa, Daijiro ;

Nishimura, Kaneyasu ;

Taniguchi, Takashi ;

Kiso, Yoshiaki ;

Yoshimoto, Kanji ;

Agatsuma, Tomohiro ;

Koide-Yoshida, Shizuyo ;

Iguchi-Ariga, Sanae M. M. ;

Shimohama, Shun ;

Ariga, Hiroyoshi .

NEUROBIOLOGY OF DISEASE, 2006, 24 (01) :144-158

[7] Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells [J].

Kinumi, T ;

Kimata, J ;

Taira, T ;

Ariga, H ;

Niki, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (03) :722-728

[8] Neuroprotective strategies in Parkinson's disease -: An update on progress [J].

Mandel, S ;

Grünblatt, E ;

Riederer, P ;

Gerlach, M ;

Levites, Y ;

Youdim, MBH .

CNS DRUGS, 2003, 17 (10) :729-762

[9] Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases [J].

Mandel, Silvia A. ;

Amit, Tamar ;

Weinreb, Orly ;

Reznichenko, Lydia ;

Youdim, Moussa B. H. .

CNS NEUROSCIENCE & THERAPEUTICS, 2008, 14 (04) :352-365

[10] Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter [J].

Manning-Bog, Amy B. ;

Caudle, W. Michael ;

Perez, Xiomara A. ;

Reaney, Stephen H. ;

Paletzki, Ronald ;

Isla, Martha Z. ;

Chou, Vivian P. ;

McCormack, Alison L. ;

Miller, Gary W. ;

Langston, J. William ;

Gerfen, Charles R. ;

DiMonte, Donato A. .

NEUROBIOLOGY OF DISEASE, 2007, 27 (02) :141-150

← 1 2 3 →