Autoimmunity IL-21: a new player in Th17-cell differentiation

被引:60
作者
Deenick, Elissa K. [1 ]
Tangye, Stuart G. [1 ]
机构
[1] Garvan Inst Med Res, Immunol & Inflammat Program, Sydney, NSW 2010, Australia
关键词
D O I
10.1038/sj.icb.7100114
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:503 / 505
页数:3
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共 23 条
[1]   Phenotypic and functional features of human Th17 cells [J].
Annunziato, Francesco ;
Cosmi, Lorenzo ;
Santarlasci, Veronica ;
Maggi, Laura ;
Liotta, Francesco ;
Mazzinghi, Benedetta ;
Parente, Eliana ;
Fili, Lucia ;
Ferri, Simona ;
Frosali, Francesca ;
Giudici, Francesco ;
Romagnani, Paola ;
Parronchi, Paola ;
Tonelli, Francesco ;
Maggi, Enrico ;
Romagnani, Sergio .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861
[2]   Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].
Bettelli, E ;
Carrier, YJ ;
Gao, WD ;
Korn, T ;
Strom, TB ;
Oukka, M ;
Weiner, HL ;
Kuchroo, VK .
NATURE, 2006, 441 (7090) :235-238
[3]   IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis [J].
Chan, Jason R. ;
Blumenschein, Wendy ;
Murphy, Erin ;
Diveu, Caroline ;
Wiekowski, Maria ;
Abbondanzo, Susan ;
Lucian, Linda ;
Geissler, Richard ;
Brodie, Scott ;
Kimball, Alexa B. ;
Gorman, Daniel M. ;
Smith, Kathleen ;
Malefyt, Rene de Waal ;
Kastelein, Robert A. ;
McClanahan, Terrill K. ;
Bowman, Edward P. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2577-2587
[4]  
Glimcher LH, 2000, GENE DEV, V14, P1693
[5]   IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression [J].
Herber, Deborah ;
Brown, Thomas P. ;
Liang, Spencer ;
Young, Deborah A. ;
Collins, Mary ;
Dunussi-Joannopoulos, Kyri .
JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3822-3830
[6]   The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells [J].
Ivanov, Ivaylo I. ;
McKenzie, Brent S. ;
Zhou, Liang ;
Tadokoro, Carlos E. ;
Lepelley, Alice ;
Lafaille, Juan J. ;
Cua, Daniel J. ;
Littman, Dan R. .
CELL, 2006, 126 (06) :1121-1133
[7]   Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation [J].
Kastelein, Robert A. ;
Hunter, Christopher A. ;
Cua, Daniel J. .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :221-242
[8]   IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells [J].
Korn, Thomas ;
Bettelli, Estelle ;
Gao, Wenda ;
Awasthi, Amit ;
Jaeger, Anneli ;
Strom, Terry B. ;
Oukka, Mohamed ;
Kuchroo, Vijay K. .
NATURE, 2007, 448 (7152) :484-U9
[9]   IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].
Langrish, CL ;
Chen, Y ;
Blumenschein, WM ;
Mattson, J ;
Basham, B ;
Sedgwick, JD ;
McClanahan, T ;
Kastelein, RA ;
Cua, DJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240
[10]   Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation [J].
Leonard, WJ ;
Spolski, R .
NATURE REVIEWS IMMUNOLOGY, 2005, 5 (09) :688-698