Crossover interference underlies sex differences in recombination rates

被引：87

作者：

Petkolv, Petko M.

Broman, Karl W.

Szatkiewicz, Jin P.

Paigen, Kenneth

机构：

[1] Jackson Lab, Ctr Genome Dynam, Bar Harbor, ME 04609 USA

[2] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 11期

关键词：

D O I：

10.1016/j.tig.2007.08.015

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects; the compaction of chromosomes at the pachytene stage of meiosis.

引用

页码：539 / 542

页数：4

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