A Novel Family of Biodegradable Poly(ester amide) Elastomers

被引：34

作者：

Cheng, Hao ^{[1
,2
]}

Hill, Paulina S. ^{[1
]}

Siegwart, Daniel J. ^{[1
]}

Vacanti, Nathaniel ^{[1
]}

Lytton-Jean, Abigail K. R. ^{[1
]}

Cho, Seung-Woo ^{[4
]}

Ye, Anne ^{[1
]}

Langer, Robert ^{[1
,2
,3
]}

Anderson, Daniel G. ^{[1
,2
,3
]}

机构：

[1] MIT, DH Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] MIT, Div Hlth Sci Technol, Cambridge, MA 02139 USA

[4] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 12期

关键词：

TISSUE; BIOMATERIALS; DELIVERY; MEDICINE; BIOLOGY; REGENERATION; HYDROGELS; POLYMERS; NERVE;

D O I：

10.1002/adma.201003482

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biodegradable elastomeric materials have particular utility in tissue engineering applications because their compliance under force closely resembles the elastic nature of many human tissues. A family of biodegradable poly(ester amide) elastomers were developed, with excellent elasticity under hydrated conditions, good in vivo biocompatibility and a slow degradation rate. This study sheds light on the structure-property relationship behind designing biodegradable elastomeric materials. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：H95 / H100

页数：6

共 29 条

[1] Silk-based biomaterials [J].

Altman, GH ;

Diaz, F ;

Jakuba, C ;

Calabro, T ;

Horan, RL ;

Chen, JS ;

Lu, H ;

Richmond, J ;

Kaplan, DL .

BIOMATERIALS, 2003, 24 (03) :401-416

[2] Curable, biodegradable elastomers: emerging biomaterials for drug delivery and tissue engineering [J].

Amsden, Brian .

SOFT MATTER, 2007, 3 (11) :1335-1348

[3] Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells [J].

Anderson, DG ;

Levenberg, S ;

Langer, R .

NATURE BIOTECHNOLOGY, 2004, 22 (07) :863-866

[4]

BARROWS TH, 1984, T SOC BIOMATER, P210

[5] Amino alcohol-based degradable poly(ester amide) elastomers [J].

Bettinger, Christopher J. ;

Bruggeman, Joost P. ;

Borenstein, Jeffrey T. ;

Langer, Robert S. .

BIOMATERIALS, 2008, 29 (15) :2315-2325

[6] Mechanical properties of acellular peripheral nerve [J].

Borschel, GH ;

Kia, KF ;

Kuzon, WM ;

Dennis, RG .

JOURNAL OF SURGICAL RESEARCH, 2003, 114 (02) :133-139

[7] Biodegradable xylitol-based polymers [J].

Bruggeman, Joost P. ;

Bettinger, Christopher J. ;

Nijst, Christiaan L. E. ;

Kohane, Daniel S. ;

Langer, Robert .

ADVANCED MATERIALS, 2008, 20 (10) :1922-+

[8] Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery [J].

Cheng, Hao ;

Kastrup, Christian J. ;

Ramanathan, Renuka ;

Siegwart, Daniel J. ;

Ma, Minglin ;

Bogatyrev, Said R. ;

Xu, Qiaobing ;

Whitehead, Kathryn A. ;

Langer, Robert ;

Anderson, Daniel G. .

ACS NANO, 2010, 4 (02) :625-631

[9] Accordion-like honeycombs for tissue engineering of cardiac anisotropy [J].

Engelmayr, George C., Jr. ;

Cheng, Mingyu ;

Bettinger, Christopher J. ;

Borenstein, Jeffrey T. ;

Langer, Robert ;

Freed, Lisa E. .

NATURE MATERIALS, 2008, 7 (12) :1003-1010

[10] Biodegradation of unsaturated poly(ester-amide)s and their hydrogels [J].

Guo, Kai ;

Chu, Chih-Chang .

BIOMATERIALS, 2007, 28 (22) :3284-3294

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