Avian influenza H5-containing virus-like particles (VLPs): Host-cell receptor specificity by STD NMR spectroscopy

被引：38

作者：

Haselhorst, Thomas ^{[1
]}

Garcia, Jean-Michel ^{[2
]}

Islam, Tasneem ^{[1
]}

Lai, Jimmy C. C. ^{[2
]}

Rose, Faith J. ^{[1
]}

Nicholls, John M. ^{[3
]}

Peiris, J. S. Malik ^{[2
]}

von Itzstein, Mark ^{[1
]}

机构：

[1] Griffith Univ, Inst Glycom, Brisbane, Qld 4222, Australia

[2] Pasteur Res Ctr Ltd, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Pathol, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 10期

基金：

英国惠康基金;

关键词：

carbohydrates; influenza; NMR spectroscopy; viruses;

D O I：

10.1002/anie.200704872

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Gripped by the flu: The emergence of a human pandemic influenza virus from an avian progenitor involves a switch in preferential binding of the influenza virus hemagglutinin (HA). Saturation transfer difference NMR spectroscopy of avian H5 chimeric virus-like particles (VLPs) encoding viral HA in a complex with α(2,3)-and α(2,6)-linked N-acetylneuraminides (3′SL and 6′SL, respectively) has shown that avian influenza H5-containing VLPs clearly discriminate between α(2,3)-and α(2,6)-linkages. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：1910 / 1912

页数：3

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