Sodium nitroprusside inhibits the tyrosine hydroxylase activity of the median eminence in the rat

被引：13

作者：

González, MC ^{[1
]}

Llorente, E ^{[1
]}

Abreu, P ^{[1
]}

机构：

[1] Univ La Laguna, Sch Med, Dept Physiol, E-38320 Tenerife, Spain

来源：

NEUROSCIENCE LETTERS | 1998年 / 254卷 / 03期

关键词：

prolactin; nitric oxide; sodium nitroprusside; tyrosine hydroxylase; dopamine;

D O I：

10.1016/S0304-3940(98)00663-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) has been involved in the modulation of various neuroendocrine responses. This work is a study of dose-response and time-course of the effect of intracerebroventricular (i.c.v.) administration of NO generator sodium nitroprusside (SNP), on tyrosine hydroxylase (TH) activity of the median eminence (ME) and serum prolactin levels, performed on conscious male rats. SNP (1, 5 and 10 mu g) inhibited the TH activity of the ME, 15 min following injection in a dose-dependent way, although the effect was only significant with the highest dose, and also increased in a dose-dependent manner the serum prolactin levels. Both actions were transient but vanished at different times following injection of 10 mu g of SNP. These results suggest that NO, released from SNP, inhibits the tuberoinfundibular dopaminergic neurons of the basal hypothalamus to stimulate prolactin secretion. (C) 1998 Elsevier Science Ireland Ltd. AII rights reserved.

引用

页码：133 / 136

页数：4

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