Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice

被引：66

作者：

Fukuda, T

Ito, H

Yoshida, T

机构：

[1] POLA Chem Ind Inc, POLA Labs, Totsuka Ku, Yokohama, Kanagawa 2440812, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

BIOFACTORS | 2004年 / 21卷 / 1-4期

关键词：

walnuts; Juglans regia; juglandaceae; antioxidant; type; 2; diabetes; C57BL-db/db mouse; 8-OHdG (8-hydroxy-2 '-deoxyguanosine);

D O I：

10.1002/biof.552210148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the in vivo antioxidative effect of a polyphenol-rich walnut extract on oxidative stress in mice with type 2 diabetes. C57BL/KsJ-db/db mice were used as an accelerated oxidative animal model. The oral administration of the walnut polyphenol fraction at 200 mg/kg body weight for 4 weeks caused a significant decrease in the level of urinary 8-hydroxy-2'-deoxyguanosin, which is an in vivo marker of oxidative stress. These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects.

引用

页码：251 / 253

页数：3

共 3 条

[1] Antioxidative polyphenols from walnuts (Juglans regia L.) [J].