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Population dynamics of immune responses to persistent viruses

被引：1018
作者：
Nowak, MA [1 ]
Bangham, CRM [1 ]
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, LONDON W2 1PG, ENGLAND
来源：
SCIENCE | 1996年 / 272卷 / 5258期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.272.5258.74
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic Tell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).
引用
收藏
页码：74 / 79
页数：6
相关论文
共 102 条
  • [1] AGUR Z, 1991, EXP HEMATOL, V19, P364
  • [2] POLYMORPHISM AND NATURAL SELECTION IN HUMAN POPULATIONS
    ALLISON, AC
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1964, 29 : 137 - +
  • [3] ANDERSON R M, 1991
  • [4] MATHEMATICAL STUDIES OF PARASITIC INFECTION AND IMMUNITY
    ANDERSON, RM
    [J]. SCIENCE, 1994, 264 (5167) : 1884 - 1886
  • [5] ANDERSON RM, 1989, CELL TO CELL SIGNALLING : FROM EXPERIMENTS TO THEORETICAL MODELS, P335
  • [6] Antigenic variation and the within-host dynamics of parasites
    Antia, R
    Nowak, MA
    Anderson, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (03) : 985 - 989
  • [7] HIV-2-SPECIFIC CYTOTOXIC T-LYMPHOCYTE ACTIVITY IS INVERSELY RELATED TO PROVIRAL LOAD
    ARIYOSHI, K
    CHAM, F
    BERRY, N
    JAFFAR, S
    SABALLY, S
    CORRAH, T
    WHITTLE, H
    [J]. AIDS, 1995, 9 (06) : 555 - 559
  • [8] NATURALLY-OCCURRING HIV-1 ISOLATES WITH DIFFERENCES IN REPLICATIVE CAPACITY ARE DISTINGUISHED BY INSITU HYBRIDIZATION OF INFECTED-CELLS
    ASJO, B
    SHARMA, UK
    MORFELDTMANSON, L
    MAGNUSSON, A
    BARKHEM, T
    ALBERT, J
    OLAUSSON, E
    VONGEGERFELT, A
    LIND, B
    BIBERFELD, P
    FENYO, EM
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (10) : 1177 - 1182
  • [9] HIV SUPPRESSION BY INTERLEUKIN-16
    BAIER, M
    WERNER, A
    BANNERT, N
    METZNER, K
    KURTH, R
    [J]. NATURE, 1995, 378 (6557) : 563 - 563
  • [10] Bangham C R, 1993, Curr Opin Neurobiol, V3, P773, DOI 10.1016/0959-4388(93)90152-O
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