Relationship between postprandial esophageal acid exposure and meal volume and fat content

被引:77
作者
Iwakiri, K
Kobayashi, M
Kotoyori, M
Yamada, H
Sugiura, T
Nakagawa, Y
机构
[1] Third Dept. of Internal Medicine, Nippon Medical School, Tokyo
[2] Third Dept. of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113, 1-1-5, Sendagi
关键词
gastroesophageal reflux; meal; fat; meal volume; intraesophageal pH monitoring;
D O I
10.1007/BF02091532
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The effect of meal volume and fat content on gastroesophageal reflux was investigated in 20 asymptomatic healthy subjects, In each subject, intraesophageal pH monitoring was performed during a 3-hr postprandial period (PP) in the same position (supine or upright) on two successive days, On day 1, 500-ml low- and high-fat meals were ingested and, on day 2, an 800-ml low-fat meal was ingested. The acid exposure time was assessed as the percentage of time with a pH < 4.0. The acid exposure time in subjects in the upright position was significantly longer in the 800-ml group than in the 500-ml group for the entire PP (2.7 +/- 1.5%; mean +/- se, 0.7 +/- 0.4%; P < 0,05). Of subjects in the supine position, the high-fat group showed significantly longer acid exposure time than the low-fat group both for the entire PP (7.6 +/- 3.0%, 0.7 +/- 0.5%; p < 0.05) and for the second hour (P < 0.05). We have demonstrated that differences in the meal volume and fat content influence gastroesophageal reflux in healthy asymptomatic subjects and that this influence varies with the position.
引用
收藏
页码:926 / 930
页数:5
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