Lithium blocks Ca-45(2+) uptake into platelets in bipolar affective disorder and controls

被引:18
作者
Berk, M [1 ]
Kirchmann, NH [1 ]
Butkow, N [1 ]
机构
[1] UNIV WITWATERSRAND, SCH MED, DEPT EXPTL & CLIN PHARMACOL, JOHANNESBURG, SOUTH AFRICA
关键词
lithium; calcium; bipolar disorder; platelets;
D O I
10.1097/00002826-199619010-00002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The basal uptake of radiolabelled Ca-45(2+) into platelets and the effect of 1 mM lithium on uptake was measured in manic (n = 13) and depressed (n = 15) patients with bipolar disorder and in controls (n = 13), Lithium was significantly associated with inhibition of uptake of Ca-45(2+) into platelets in all three groups, There were no significant intergroup differences in either basal levels of calcium uptake or the effects of lithium on calcium uptake (analysis of variance).
引用
收藏
页码:48 / 51
页数:4
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