Evaluation of tumor oxygenation by color duplex sonography: A new approach

被引：8

作者：

Di Martino, EFN

Gagel, B

Schramm, O

Maneschi, P

Westhofen, M

机构：

[1] Rhein Westfal TH Aachen, Dept Otothinolaryngol & Plast Head & Neck Surg, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Dept Radiotherapy, D-52074 Aachen, Germany

[3] Univ Heidelberg, Dept Radiol, D-6900 Heidelberg, Germany

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2005年 / 132卷 / 05期

关键词：

D O I：

10.1016/j.otohns.2005.01.033

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE Description of a new noninvasive method for the evaluation of tissue oxygenation in head and neck cancer. STUDY DESIGN AND SETTING: Prospective nonrandomized controlled study in an academic medical center on 20 patients with neck metastases of head and neck cancer. Metastases were investigated using color duplex sonography and pO(2) histography. The vascularization in sonography was quantitatively evaluated by color pixel density and compared to the pO(2) values of the same nodes. RESULTS: The correlation between vascularization and flow velocity was 0.71. For the mean/median pO(2)-values and for the pO(2) readings &LT; 10.0 mmHg correlations were r = 0.65 / 0.76 and 0.71. CONCLUSION: This sonographic method allows a safe and reliable evaluation of oxygenation in metastases of head and neck cancer. SIGNIFICANCE: The new approach is an alternative to pO(2) histography and may play a future role in the planning of radiotherapy in the neck.

引用

收藏

页码：765 / 769

页数：5

相关论文

共 20 条

[1] Oxygenation of squamous cell carcinoma of the head and neck:: Comparison of primary tumors, neck node metastases, and normal tissue [J].

Becker, A ;

Hänsgen, G ;

Bloching, M ;

Weigel, C ;

Lautenschläger, C ;

Dunst, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (01) :35-41

[2] Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck [J].

Brizel, DM ;

Sibley, GS ;

Prosnitz, LR ;

Scher, RL ;

Dewhirst, MW .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 38 (02) :285-289

[3] Sensitivity of color Doppler sonography: An experimental approach [J].

Delorme, S ;

Peschke, P ;

Zuna, I ;

Van Kaick, G .

ULTRASOUND IN MEDICINE AND BIOLOGY, 1999, 25 (04) :541-547

[4] Color duplex sonography in post-therapeutic neck evaluation [J].

Di Martino, E ;

Krombach, GA ;

Nowak, B ;

Sellhaus, B ;

Schmitz-Rode, T ;

Hausmann, R ;

Westhofen, M .

AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2002, 23 (03) :153-159

[5] Rise of oxygenation in cervical lymph node metastasis during the initial course of radiochemotherapy [J].

Dietz, A ;

Rudat, V ;

Vanselow, B ;

Wollensack, P ;

Bettscheider, C ;

Conradt, C ;

Elbe, MJ .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1999, 121 (06) :789-796

[6] Prognostic impact of reoxygenation in advanced cancer of the head and neck during the initial course of chemoradiation or radiotherapy alone [J].

Dietz, A ;

Vanselow, B ;

Rudat, V ;

Conradt, C ;

Weidauer, H ;

Kallinowski, F ;

Dollner, R .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2003, 25 (01) :50-58

[7] Tumor volume and tumor hypoxia in head and neck cancers -: The amount of the hypoxic volume is important [J].

Dunst, J ;

Stadler, P ;

Becker, A ;

Lautenschläger, C ;

Pelz, T ;

Hänsgen, G ;

Molls, M ;

Kuhnt, T .

STRAHLENTHERAPIE UND ONKOLOGIE, 2003, 179 (08) :521-+

[8] THE EFFECT OF OXYGEN BREATHING AND RADIOTHERAPY UPON THE TISSUE OXYGEN TENSION OF SOME HUMAN TUMOURS [J].

EVANS, NTS ;

NAYLOR, PFD .

BRITISH JOURNAL OF RADIOLOGY, 1963, 36 (426) :418-425

[9] Quantified color Doppler sonography of tumor vascularity in an animal model [J].

Fleischer, AC ;

Wojcicki, WE ;

Donnelly, EF ;

Pickens, DR ;

Thirsk, G ;

Thurman, GB ;

Hellerqvist, CG .

JOURNAL OF ULTRASOUND IN MEDICINE, 1999, 18 (08) :547-551

[10]

Hockel M, 1996, CANCER RES, V56, P4509