Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope

被引：63

作者：

An, DS ^{[1
]}

Xie, YM ^{[1
]}

Chen, ISY ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Immunol Mol Genet & Med, AIDS Inst, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 07期

关键词：

D O I：

10.1128/JVI.75.7.3488-3489.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A member of the human endogenous retrovirus (HERV) family termed HERV-W encodes a highly fusogenic membrane glycoprotein that appears to be expressed specifically in the placenta. It is unclear whether the glycoproteins of the HERVs can serve as functional retrovirus envelope proteins to confer infectivity on retrovirus particles. We found that the HERV-W envelope glycoprotein can form pseudotypes with human immunodeficiency virus type 1 virions and confers tropism for CD4-negative cells. Thus, the HERV-W env gene represents the first HERV env gene demonstrated to encode the functional properties of a retrovirus envelope glycoprotein.

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页码：3488 / 3489

页数：2

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