Can we replace the 90-minute thrombolysis in myocardial infarction (TIMI) flow grades with those at 60 minutes as a primary end point in thrombolytic trials?

被引：6

作者：

Gibson, CM

Murphy, SA

Marble, SJ

McCabe, CH

Antman, EM

Cannon, CP

Braunwald, E

机构：

[1] Univ Calif San Francisco, Dept Med, Div Cardiovasc, San Francisco, CA 94118 USA

[2] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 04期

关键词：

D O I：

10.1016/S0002-9149(00)01402-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The establishment of patency (Thrombolysis In Myocardial Infarction [TIMI] grade 2 or 3 flow) and/or TIMI grade 3 flow at 60 minutes after thrombolytic administration is both a univariate and multivariate predictor of in-hospital and 30-day mortality, and the odds ratios for mortality are nearly identical for TIMI grade 3 flow at 60 and 90 minutes, Thus, the 60-minute angiographic end point appears to be a valid alternative to that at 90 minutes and may permit earlier decisions regarding post-thrombolytic intervention.

引用

页码：450 / +

页数：5

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