Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease

被引：105

作者：

Caslake, MJ ^{[1
]}

Packard, CJ ^{[1
]}

机构：

[1] Royal Infirm, Dept Pathol Biochem, Glasgow G31 2ER, Lanark, Scotland

来源：

CURRENT OPINION IN LIPIDOLOGY | 2003年 / 14卷 / 04期

关键词：

inflammation; LDL; HDL; atherosclerosis; oxidized lipoproteins;

D O I：

10.1097/00041433-200308000-00002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lp-PLA(2) is an enzyme with potentially multiple risks in atherosclerosis. In humans the weight of evidence suggests that it is a positive risk factor for coronary heart disease - an observation commensurate with its position in the direct pathological sequence leading from formation of oxidized LDL in the artery wall to cellular dysfunction and formation of lesions.

引用

页码：347 / 352

页数：6

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