The synthesis of optically pure enantiomers of N-acyl-homoserine lactone autoinducers and their analogues

被引：42

作者：

Ikeda, T ^{[1
]}

Kajiyama, K ^{[1
]}

Kita, T ^{[1
]}

Takiguchi, N ^{[1
]}

Kuroda, A ^{[1
]}

Kato, J ^{[1
]}

Ohtake, H ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Fermentat Technol, Hiroshima 7398527, Japan

来源：

CHEMISTRY LETTERS | 2001年 / 04期

关键词：

D O I：

10.1246/cl.2001.314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optically pure enantiomers of N-acyl-homoserine lactones and thiolactones, whose optical purities were unambiguously determined by chiral stationary phase HPLC analyses, were firstly synthesized. Bioassays revealed that L-isomers were essential as the autoinducers in quorum sensing, while no effect was observed with D-isomers.

引用

页码：314 / 315

页数：2

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