Cell migration in the forebrain

被引：711

作者：

Marín, O

Rubenstein, JLR

机构：

[1] Univ Miguel Hernandez, CSIC, Unidad Neurobiol Desarrollo, Inst Neurosci, Alacant 03550, Spain

[2] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, Langley Porter Psychiat Inst, San Francisco, CA 94143 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2003年 / 26卷

关键词：

radial; tangential; interneuron; pyramidal neuron; telencephalon;

D O I：

10.1146/annurev.neuro.26.041002.131058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The forebrain comprises an intricate set of structures that are required for some of the most complex and evolved functions of the mammalian brain. As a reflection of its complexity, cell migration in the forebrain is extremely elaborated, with widespread dispersion of cells across multiple functionally distinct areas. Two general modes of migration are distinguished in the forebrain: radial migration, which establishes the general cytoarchitectonical framework of the different forebrain subdivisions; and tangential migration, which increases the cellular complexity of forebrain circuits by allowing the dispersion of multiple neuronal types. Here, we review the cellular and molecular mechanisms underlying each of these types of migrations and discuss how emerging concepts in neuronal migration are reshaping our understanding of forebrain development in normal and pathological situations.

引用

页码：441 / 483

页数：43

共 300 条

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