TAMpering with toll-like receptor signaling

被引：36

作者：

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

CELL | 2007年 / 131卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.11.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.

引用

页码：1039 / 1041

页数：3

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