Production of [F-18]F-2 using the O-16(He-3,p)F-18 reaction

被引：5

作者：

Bishop, A

Satyamurthy, N

Bida, G

Phelps, M

Barrio, JR

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT MOL & MED PHARMACOL,DIV NUCL MED,LOS ANGELES,CA 90095

[2] US DOE,LAB STRUCT BIOL & MOL MED,LOS ANGELES,CA 90095

[3] BIOMED RES FDN NW LOUISIANA,SHREVEPORT,LA 71103

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 04期

关键词：

F-18]F-2; O-16(He-3; p)F-18; reaction; aluminum target body; 6-[F-18]fluoro-L-dopa;

D O I：

10.1016/0969-8051(95)02009-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

For the first time, the O-16(He-3,p)F-18 reaction has been used for the production of F-18 electrophilic reagents. The predominant reactive chemical specie recovered in the single step postirradiation gases was [F-18]F-2. Decay curve and Ge(Li) analyses established the main radionuclidic impurities in this nuclear reaction as C-11 and O-15. Recovery of the F-18 activity was exceptionally high, approaching 90% using an electroformed nickel target body. Consistent F-18 recoveries for this nuclear reaction (similar to 70%) were realized with a novel aluminum target body, The utility of the [F-18]F-2 recovered from this oxygen gas target system in radiopharmaceutical preparations is demonstrated by the successful synthesis of 6-[F-18]fluoro-L dopa (11.0 mCi at FOB) via a fluorodemercuration method.

引用

页码：385 / 389

页数：5

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