Molecular piracy of Kaposi's sarcoma associated herpesvirus

被引：30

作者：

Choi, JK ^{[1
]}

Means, RE ^{[1
]}

Damania, B ^{[1
]}

Jung, JU ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Div Tumor Virol,New England Reg Primate Res Ctr, Southborough, MA 01772 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2001年 / 12卷 / 2-3期

关键词：

Kaposi's sarcoma associated herpesvirus; molecular piracy; oncoprotein; signal transduction; immune evasion; viral cytokine homologs; viral antiapoptotic genes;

D O I：

10.1016/S1359-6101(00)00029-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kaposi's Sarcoma associated Herpesvirus (KSHV) is the most recently discovered human tumor virus and is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and Multicentric Casttleman's disease. KSHV contains numerous open reading frames with striking homology to cellular genes. These viral gene products play a variety of roles in KSHV-associated pathogenesis by disrupting cellular signal transduction pathways, which include interferon-mediated anti-viral responses. cytokine-regulated cell growth, apoptosis, and cell cycle control. In this review, we will attempt to cover our understanding of how viral proteins deregulate cellular signaling pathways. which ultimately contribute to the conversion of normal cells to cancerous cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：245 / 257

页数：13

共 135 条

[1]

ABLASHI DV, 1985, CANCER RES, V45, P3981

[2] Chemokines: Leucocyte recruitment and activation cytokines [J].