Viruses and bacteria in acute asthma exacerbations - A GA2LEN-DARE* systematic review

被引：227

作者：

Papadopoulos, N. G. ^{[1
]}

Christodoulou, I. ^{[1
]}

Rohde, G. ^{[2
]}

Agache, I. ^{[3
]}

Almqvist, C. ^{[4
]}

Bruno, A. ^{[5
]}

Bonini, S. ^{[6
]}

Bont, L. ^{[7
]}

Bossios, A. ^{[8
]}

Bousquet, J. ^{[9
]}

Braido, F. ^{[10
]}

Brusselle, G. ^{[11
]}

Canonica, G. W. ^{[10
]}

Carlsen, K. H. ^{[12
]}

Chanez, P. ^{[9
]}

Fokkens, W. J. ^{[13
]}

Garcia-Garcia, M. ^{[14
]}

Gjomarkaj, M. ^{[5
]}

Haahtela, T. ^{[15
]}

Holgate, S. T. ^{[16
]}

Johnston, S. L. ^{[17
]}

Konstantinou, G. ^{[1
]}

Kowalski, M. ^{[8
]}

Lewandowska-Polak, A. ^{[18
]}

Lodrup-Carlsen, K. ^{[12
]}

Makela, M. ^{[15
]}

Malkusova, I. ^{[19
]}

Mullol, J. ^{[20
]}

Nieto, A. ^{[21
]}

Eller, E. ^{[22
]}

Ozdemir, C. ^{[23
]}

Panzner, P. ^{[19
]}

Popov, T. ^{[24
]}

Psarras, S. ^{[25
]}

Roumpedaki, E. ^{[1
]}

Rukhadze, M. ^{[26
]}

Stipic-Markovic, A. ^{[27
]}

Bom, A. Todo ^{[28
]}

Toskala, E. ^{[29
]}

van Cauwenberge, P. ^{[11
]}

van Drunen, C. ^{[13
]}

Watelet, J. B. ^{[11
]}

Xatzipsalti, M. ^{[1
]}

Xepapadaki, P. ^{[1
]}

Zuberbier, T. ^{[30
]}

机构：

[1] Natl & Kapodistrian Univ, Pediat Clin 2, Dept Allergy, Athens, Greece

[2] Maastricht Univ Med Ctr, Dept Resp Med, Maastricht, Netherlands

[3] Transylvania Univ, Dept Allergy & Clin Immunol, Brasov, Romania

[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[5] CNR, Ist Biomed, Palermo, Italy

[6] CNR, Rome, Italy

[7] Univ Med Ctr, Utrecht, Netherlands

[8] Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Gothenburg, Sweden

[9] Univ Hosp, Montpellier, France

[10] Univ Genoa, Allergy & Resp Dept, Genoa, Italy

[11] Ghent Univ Hosp, Dept Otorhinolaryngol, B-9000 Ghent, Belgium

[12] Natl Hosp Norway, Oslo Univ Hosp, Oslo, Norway

[13] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolarygol, NL-1105 AZ Amsterdam, Netherlands

[14] Severo Ochoa Hosp, Dept Pediat, Madrid, Spain

[15] Helsinki Univ Hosp, Skin & Allergy Hosp, Dept Allergy, Helsinki, Finland

[16] Univ Southampton, Resp Cell & Mol Biol Res Div, Southampton SO9 5NH, Hants, England

[17] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[18] Med Univ Lodz, Dept Immunol, Lodz, Poland

[19] Charles Univ Prague, Fac Med, Dept Allergol & Immunol, Plzen, Czech Republic

[20] CIBERES, IDIBAPS, Hosp Clin, ENT Dept, Barcelona, Catalonia, Spain

[21] Childrens Hosp La Fe, Pediat Allergy Unit, Valencia, Spain

[22] Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark

[23] Marmara Univ Med Fac, Div Pediat Allergy & Immunol, Istanbul, Turkey

[24] Med Univ, Alexandrovska Hosp, Clin Ctr Allergol, Sofia, Bulgaria

[25] Acad Athens, Biomed Res Fdn, Athens, Greece

[26] Ctr Allergy & Immunol, Tbilisi, Georgia

[27] Univ Zagreb, Sveti Duh Gen Hosp, Dept Clin Immunol Pulmonol & Rheumatol, HR-10002 Zagreb, Croatia

[28] Univ Coimbra, Coimbra, Portugal

[29] Finnish Inst Occupat Hlth, Helsinki, Finland

[30] Allergy Ctr Charite, Dept Dermatol & Allergy, Berlin, Germany

来源：

ALLERGY | 2011年 / 66卷 / 04期

基金：

英国医学研究理事会;

关键词：

asthma exacerbation; atypical bacteria; detection method; PCR; respiratory virus; RESPIRATORY SYNCYTIAL VIRUS; HUMAN METAPNEUMOVIRUS INFECTION; MYCOPLASMA-PNEUMONIAE INFECTIONS; COMMUNITY-ACQUIRED PNEUMONIA; POLYMERASE-CHAIN-REACTION; HUMAN CORONAVIRUS NL63; CHLAMYDIA-PNEUMONIAE; VIRAL-INFECTIONS; TRACT INFECTIONS; YOUNG-CHILDREN;

D O I：

10.1111/j.1398-9995.2010.02505.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

P>A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This systematic review summarizes current knowledge and developments in infection epidemiology of acute asthma in children and adults, describing the known impact for each individual agent and highlighting knowledge gaps. Among infectious agents, human rhinoviruses are the most prevalent in regard to asthma exacerbations. The newly identified type-C rhinoviruses may prove to be particularly relevant. Respiratory syncytial virus and metapneumovirus are important in infants, while influenza viruses seem to induce severe exacerbations mostly in adults. Other agents are relatively less or not clearly associated. Mycoplasma and Chlamydophila pneumoniae seem to be involved more with asthma persistence rather than with disease exacerbations. Recent data suggest that common bacteria may also be involved, but this should be confirmed. Although current information is considerable, improvements in detection methodologies, as well as the wide variation in respect to location, time and populations, underline the need for additional studies that should also take into account interacting factors.

引用

页码：458 / 468

页数：11

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