Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

被引：283

作者：

Lu, Ching-Lan ^{[1
,2
]}

Murakowski, Dariusz K. ^{[3
]}

Bournazos, Stylianos ^{[4
]}

Schoofs, Till ^{[1
]}

Sarkar, Debolina ^{[3
]}

Halper-Stromberg, Ariel ^{[1
]}

Horwitz, Joshua A. ^{[1
]}

Nogueira, Lilian ^{[1
]}

Golijanin, Jovana ^{[1
]}

Gazumyan, Anna ^{[1
]}

Ravetch, Jeffrey V. ^{[4
]}

Caskey, Marina ^{[1
]}

Chakraborty, Arup K. ^{[3
,5
,6
,7
,8
]}

Nussenzweig, Michel C. ^{[1
,9
]}

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

[2] Weill Cornell Med Coll, New York, NY 10065 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] Rockefeller Univ, Lab Mol Genet & Immunol, New York, NY 10065 USA

[5] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[6] MIT, Dept Phys, Cambridge, MA 02139 USA

[7] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[8] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[9] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

SCIENCE | 2016年 / 352卷 / 6288期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; DEPENDENT CELLULAR CYTOTOXICITY; EFFECTOR FUNCTIONS; MOUSE MODEL; THERAPY; VACCINE; PREVENTION; RESPONSES; EFFICACY; IMMUNITY;

D O I：

10.1126/science.aaf1279

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antiretroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life cycle. In addition, antibodies also have the potential to guide host immune effector cells to kill HIV-1-infected cells. Examination of the kinetics of HIV-1 suppression in infected individuals by passively administered 3BNC117, a broadly neutralizing antibody, suggested that the effects of the antibody are not limited to free viral clearance and blocking new infection but also include acceleration of infected cell clearance. Consistent with these observations, we find that broadly neutralizing antibodies can target CD4(+) T cells infected with patient viruses and can decrease their in vivo half-lives by a mechanism that requires Fc gamma receptor engagement in a humanized mouse model. The results indicate that passive immunotherapy can accelerate elimination of HIV-1-infected cells.

引用

页码：1001 / 1004

页数：4

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