mTOR: from growth signal integration to cancer, diabetes and ageing

被引：3224

作者：

Zoncu, Roberto ^{[1
]}

Efeyan, Alejo ^{[1
]}

Sabatini, David M. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

LIFE-SPAN EXTENSION; P70; S6; KINASE; TUBEROUS SCLEROSIS COMPLEX; MESSENGER-RNA TRANSLATION; CELL-GROWTH; MAMMALIAN TARGET; PROTEIN-KINASE; CAENORHABDITIS-ELEGANS; TRANSCRIPTION FACTOR; AMINO-ACIDS;

D O I：

10.1038/nrm3025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.

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收藏

页码：21 / 35

页数：15

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