Body mass and physical activity and risk of gastric cancer in a population-based cohort study in Norway

被引:51
作者
Sjodahl, Krister [1 ]
Jia, Chongqi [1 ,2 ,3 ]
Vatten, Lars [4 ]
Nilsen, Tom [4 ]
Hveem, Kristian [4 ]
Lagergren, Jesper [1 ]
机构
[1] Karolinska Inst, Dept Mol Med & Surg, Unit Esophageal & Gastr Res, SE-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17176 Stockholm, Sweden
[3] Shandong Univ, Dept Epidemiol & Hlth Stat, Shandong, Peoples R China
[4] Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7034 Trondheim, Norway
关键词
D O I
10.1158/1055-9965.EPI-07-0704
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is a relation between excess body mass index and overall cancer incidence and mortality, but the relation to noncardia gastric cancer is inconsistent. A high physical activity level decreases the risk of several cancers, but few studies have focused on gastric cancer. We conducted a population-based, prospective cohort study in Nord-Trondelag county in Norway. During 1984 to 1986, all adult residents were invited to participate in a health survey, where body height and weight were measured, and frequency, duration, and intensity of recreational physical activity, together with potential confounding factors, were assessed by questionnaires. New gastric cancers occurring during followup in 1984 to 2002 were identified by linkage to the Cancer Registry of Norway. Cox proportional hazards regression models were used to calculate hazard ratios with 95% confidence intervals, adjusted for age, sex, occupation, salt intake, smoking, and alcohol drinking. Follow-up of 73,133 cohort members (88% of all inhabitants) revealed 313 gastric cancers, including 264 noncardia cancers. No statistically significant associations were revealed between different levels of body mass index and risk of noncardia gastric cancer. A statistically significant 50% risk reduction among persons reporting at least a moderate level of recreational physical activity, based on a summary score of physical activity (hazard ratio, 0.5; 95% confidence interval, 0.3-0.9), and a dose-response relation was indicated (P for trend = 0.01). It is concluded that recreational physical activity might have a protective effect against gastric cancer. The sedentary lifestyle gaining ground in western societies might counteract the ongoing decrease in incidence of gastric cancer.
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页码:135 / 140
页数:6
相关论文
共 41 条
[1]  
[Anonymous], 1994, IARC Monogr Eval Carcinog Risks Hum, V61, P1
[2]  
BRAY F, 2005, CANC NORWAY
[3]   Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].
Calle, EE ;
Rodriguez, C ;
Walker-Thurmond, K ;
Thun, MJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1625-1638
[4]  
Chatenoud L, 1999, AM J CLIN NUTR, V70, P1107
[5]   Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia [J].
Chow, WH ;
Blot, WJ ;
Vaughn, TL ;
Risch, HA ;
Gammon, MD ;
Stanford, JL ;
Dubrow, R ;
Schoenberg, JB ;
Mayne, ST ;
Farrow, DC ;
Ahsan, H ;
West, AB ;
Rotterdam, H ;
Niwa, S ;
Fraumeni, JF .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (02) :150-155
[6]   Dietary patterns and risk of gastric cancer: A case-control study in Uruguay [J].
De Stefani E. ;
Correa P. ;
Boffetta P. ;
Deneo-Pellegrini H. ;
Ronco A.L. ;
Mendilaharsu M. .
Gastric Cancer, 2004, 7 (4) :211-220
[7]  
DEBURGOS AM, 1992, EUR J CLIN NUTR, V46, P803
[8]   Gastric cancer: global pattern of the disease and an overview of environmental risk factors [J].
Forman, D. ;
Burley, V. J. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2006, 20 (04) :633-649
[9]   Physical activity and cancer prevention: Etiologic evidence and biological mechanisms [J].
Friedenreich, CM ;
Orenstein, MR .
JOURNAL OF NUTRITION, 2002, 132 (11) :3456S-3464S
[10]  
Friedenreich CM, 2001, CANCER EPIDEM BIOMAR, V10, P287